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compusyn software (version 1.0  (ComboSyn Inc)
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(A) Concentration-response curve from etoposide treatment in A549 cells. (B) Bar graph showing the cell viability determined by MTT assay in A549 cells at different concentrations of R. junceus venom (½IC 50 , IC 50 , 2xIC 50 ) combined with etoposide (IC 50 ). Untreated cells represent 100% cell viability. The culture medium was used as the negative control. *p < 0.05 respect to etoposide as a single treatment. The experiments were performed three times with five technical replicates. (C) Normalized isobologram of in vitro drug-to-drug interaction between R. junceus venom (RjSV) and etoposide (Eto) in A549 cancer cell line based on <t>CompuSyn</t> analysis from MTT data. (D) Representative cell cycle histogram and bar graph summary representing the percentage of cells in G0/G1, S, and G2/M after 48-h treatment. Bars represent an average of six measurements. (E) Representative scatter plot of PI (y-axis) and Annexin-V (x-axis) as measurements of apoptotic cell death and bar graph of the percentage of total apoptosis determined by flow cytometry (n = 6). *p < 0.05 compared to the control (the culture media in absence of scorpion venom) from the ANOVA test.
Compusyn Software (Version 1.0, supplied by ComboSyn Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/compusyn software (version 1.0/product/ComboSyn Inc
Average 90 stars, based on 1 article reviews
compusyn software (version 1.0 - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier
compusyn version 1.0 software  (ComboSyn Inc)
90
ComboSyn Inc compusyn version 1.0 software
(A) Concentration-response curve from etoposide treatment in A549 cells. (B) Bar graph showing the cell viability determined by MTT assay in A549 cells at different concentrations of R. junceus venom (½IC 50 , IC 50 , 2xIC 50 ) combined with etoposide (IC 50 ). Untreated cells represent 100% cell viability. The culture medium was used as the negative control. *p < 0.05 respect to etoposide as a single treatment. The experiments were performed three times with five technical replicates. (C) Normalized isobologram of in vitro drug-to-drug interaction between R. junceus venom (RjSV) and etoposide (Eto) in A549 cancer cell line based on <t>CompuSyn</t> analysis from MTT data. (D) Representative cell cycle histogram and bar graph summary representing the percentage of cells in G0/G1, S, and G2/M after 48-h treatment. Bars represent an average of six measurements. (E) Representative scatter plot of PI (y-axis) and Annexin-V (x-axis) as measurements of apoptotic cell death and bar graph of the percentage of total apoptosis determined by flow cytometry (n = 6). *p < 0.05 compared to the control (the culture media in absence of scorpion venom) from the ANOVA test.
Compusyn Version 1.0 Software, supplied by ComboSyn Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/compusyn version 1.0 software/product/ComboSyn Inc
Average 90 stars, based on 1 article reviews
compusyn version 1.0 software - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier
compusyn software program version 1.0  (ComboSyn Inc)
90
ComboSyn Inc compusyn software program version 1.0
(A) Concentration-response curve from etoposide treatment in A549 cells. (B) Bar graph showing the cell viability determined by MTT assay in A549 cells at different concentrations of R. junceus venom (½IC 50 , IC 50 , 2xIC 50 ) combined with etoposide (IC 50 ). Untreated cells represent 100% cell viability. The culture medium was used as the negative control. *p < 0.05 respect to etoposide as a single treatment. The experiments were performed three times with five technical replicates. (C) Normalized isobologram of in vitro drug-to-drug interaction between R. junceus venom (RjSV) and etoposide (Eto) in A549 cancer cell line based on <t>CompuSyn</t> analysis from MTT data. (D) Representative cell cycle histogram and bar graph summary representing the percentage of cells in G0/G1, S, and G2/M after 48-h treatment. Bars represent an average of six measurements. (E) Representative scatter plot of PI (y-axis) and Annexin-V (x-axis) as measurements of apoptotic cell death and bar graph of the percentage of total apoptosis determined by flow cytometry (n = 6). *p < 0.05 compared to the control (the culture media in absence of scorpion venom) from the ANOVA test.
Compusyn Software Program Version 1.0, supplied by ComboSyn Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/compusyn software program version 1.0/product/ComboSyn Inc
Average 90 stars, based on 1 article reviews
compusyn software program version 1.0 - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier

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(A) Concentration-response curve from etoposide treatment in A549 cells. (B) Bar graph showing the cell viability determined by MTT assay in A549 cells at different concentrations of R. junceus venom (½IC 50 , IC 50 , 2xIC 50 ) combined with etoposide (IC 50 ). Untreated cells represent 100% cell viability. The culture medium was used as the negative control. *p < 0.05 respect to etoposide as a single treatment. The experiments were performed three times with five technical replicates. (C) Normalized isobologram of in vitro drug-to-drug interaction between R. junceus venom (RjSV) and etoposide (Eto) in A549 cancer cell line based on CompuSyn analysis from MTT data. (D) Representative cell cycle histogram and bar graph summary representing the percentage of cells in G0/G1, S, and G2/M after 48-h treatment. Bars represent an average of six measurements. (E) Representative scatter plot of PI (y-axis) and Annexin-V (x-axis) as measurements of apoptotic cell death and bar graph of the percentage of total apoptosis determined by flow cytometry (n = 6). *p < 0.05 compared to the control (the culture media in absence of scorpion venom) from the ANOVA test.

Journal: The Journal of Venomous Animals and Toxins Including Tropical Diseases

Article Title: Rhopalurus junceus scorpion venom induces G2/M cell cycle arrest and apoptotic cell death in human non-small lung cancer cell lines

doi: 10.1590/1678-9199-JVATITD-2024-0035

Figure Lengend Snippet: (A) Concentration-response curve from etoposide treatment in A549 cells. (B) Bar graph showing the cell viability determined by MTT assay in A549 cells at different concentrations of R. junceus venom (½IC 50 , IC 50 , 2xIC 50 ) combined with etoposide (IC 50 ). Untreated cells represent 100% cell viability. The culture medium was used as the negative control. *p < 0.05 respect to etoposide as a single treatment. The experiments were performed three times with five technical replicates. (C) Normalized isobologram of in vitro drug-to-drug interaction between R. junceus venom (RjSV) and etoposide (Eto) in A549 cancer cell line based on CompuSyn analysis from MTT data. (D) Representative cell cycle histogram and bar graph summary representing the percentage of cells in G0/G1, S, and G2/M after 48-h treatment. Bars represent an average of six measurements. (E) Representative scatter plot of PI (y-axis) and Annexin-V (x-axis) as measurements of apoptotic cell death and bar graph of the percentage of total apoptosis determined by flow cytometry (n = 6). *p < 0.05 compared to the control (the culture media in absence of scorpion venom) from the ANOVA test.

Article Snippet: The CI was generated automatically using CompuSyn software (version 1.0; ComboSyn, Inc., Paramus, NJ, USA), as previously described by Chou [ ].

Techniques: Concentration Assay, MTT Assay, Negative Control, In Vitro, Flow Cytometry, Control